Still more links and excerpts on Prolotherapy for Meniscus Repair
Still more links and excerpts:
http://www.kneeguru.co.uk/KNEEtalk/index.php?topic=46074.msg485454#msg485454
“I think we are going to see quite a lot of stem cell based treatments suspended within scafolds over the next few years...Off top of my head a company called mesoblast are hoping to release a off shelf stem cell product by 2012 and another company from Canada called BST are releasing a product called cargel in 2010 - results from the trials are coming out late this year and ealry next - the intial results - MRI and Biopsie showed improve cartilage tissue quauilty compard to microfracture - another company called Tringenix also bought a uk company which has a scafold type product which soaks up stem cells from the bone and repairs defects - thats expected to hit european markets next year also.”
--thevoice Reply #135 on: December 20, 2009, 09:47:52 PM
http://www.kneeguru.co.uk/KNEEtalk/index.php?topic=46074.msg524234#msg524234
Re: PRP injections are regenerating my knee cartilage & ligaments
« Reply #210 on: November 23, 2010, 02:11:17 PM »
________________________________________
Nick,
Prolo with and without PRP has served me very well. I've cured my lower back and shoulder of a lot of pain using the Hemdall Hacket treatment method. However, when it came to my knee, it did about half the job. It stabilized the joint and strengthened the knee ligaments, but wasn't as affective in regenerating cartilage.
So I looked into Regenexx, spoke with a few on this forum to get their insights and experience with Regenexx, and decided to give it a try.Via MRI, my MD was able to point out that my lateral meniscus, or what's left of it after meniscectomy, was squeezed outside of the joint leaving me bone on bone at the lateral posterial horn of the right knee joint. So no amount of Prolo was going to help and they need to first correct the misplacement of the meniscus before injecting stem cells to regenerate the articular cartilage.
The clinics suggestion, as a first step, was to correct the misalignment of the meniscus that was squeezed out of position. They inserted a fat graph (which contains adipose stem cells) into the corner of the joint, to hold the meniscus in its proper place and provide cushion between the femur and tibia. I watched the procedure using ultra sound. it was amazing watching on screen, just by positioning my knee a certain angle while laying sideways on my side, the joint opened and I watched the meniscus get sucked back into proper position. then the MD injected the fat graph mixed with their own concoction of PRP (supposedly 3x more powerful than bedside PRP) to hold the meniscus in place. I'm now fitted with a lateral unloader for 6 weeks while it heals.
So my condition is somewhat unique and required a more complicated solution than what regular prolo could provide.
My next visit they will do the marrow draw for the Mesenchymal stem cells for regenerating the articular cartilage.
what's frustrating to me is that no MD ever pointed out this meniscus problem before after analyzing my MRI. My regenexx did find it. doc likes to refer to it as the "money shot" and I got a printout of it, that shows my damaged meniscus sqeezed out of the joint.
Anyways, time will tell if this hypothetical works. I'll have the ultra sound in 5 weeks that will show if this fat graph procedure was a success.
gb
http://www.kneeguru.co.uk/KNEEtalk/index.php?topic=46074.240
Re: PRP injections are regenerating my knee cartilage & ligaments
« Reply #240 on: January 04, 2011, 03:19:35 AM »
________________________________________
ashok_guru
here's an update on my fat graph.
Regenexx posted my fat graph procedure results to their website. I guess they were happy with the results and decided to share with the world
the pic is of an ultrasound snapshot of my knee with commentary, 1 month after the fat graph injection. just follow the link below. that's my knee!
http://www.regenexx.com/2010/12/regenexx-ad-fat-graft-survival/
so far, the integrity of the graph is intact and holding the meniscus in its proper place. ~ roughly 40% of lateral meniscus is all thats left and had spit itself outside the knee joint leaving me bone on bone. Apparently its a common problem with patients who've had a menisectomy. this procedure has fixed it providing me with the cushion between the tibia and femur.
the stiffness in my lateral joint is GONE. can hardly believe it. but its only been a 2 months, we'll see if it holds up.
too early to tell if the MSC injections (i had this procedure 1 month after the fat graft procedure) have regenerated cartilage. i'm not allowed MRI on the knee for at least 6 months following the last injection. MRI's are bad for the stem cells. so difficult to tell at this point.
gb
http://www.kneeguru.co.uk/KNEEtalk/index.php?topic=46074.msg544488#msg544488
Re: PRP injections are regenerating my knee cartilage & ligaments
« Reply #268 on: May 04, 2011, 01:11:47 AM »
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MTLBAB,
Just following directions by my MD at Regenexx. I personally don't have any data for you.
BTW, i'll be providing an update soon. Its been 6 months since my first regenexx procedure on my knees (degenerative knee + a displaced lateral meniscus that was squeezed out of the joint) and the results have been very good. I've experienced many PRP and prolo from the the Hauser clinic in Chicago and 3 visits for the regenexx's stem cell procedure, and in my opinion, for cartilage repair, ie. articular cartilage and meniscus, regenexx is by far the better option. More potent, more powerful and much more acccurate. (very important!)
gb
“Study Finds Collagen-Producing Cells Heal Patients Faster Than Only Plasma for Tendinopathy“
Written by Laura Miller | December 09, 2010
http://beckersorthopedicandspine.com/sports-medicine/item/2646-S
“Platelet-Rich Plasma Injections Treat the Underlying Cause of Knee Arthritis, Notes Cleveland-area Orthopedist Robert Zanotti, MD”
http://www.prweb.com/releases/PRP/injections/prweb4706744.htm
“Tiger Takes Another Shot: PRP Injections Put On the Spot”
http://www.prweb.com/releases/tigerwoods/prpinjection/prweb4135604.htm
American Journal of Physical Medicine & Rehabilitation: December 2010 - Volume 89 - Issue 12 - pp 961-969
doi: 10.1097/PHM.0b013e3181fc7edf
“Injection of Platelet-Rich Plasma in Patients with Primary and Secondary Knee Osteoarthritis: A Pilot Study”
http://journals.lww.com/ajpmr/pages/viewallmostpopulararticles.aspx
[click on “Free” icon]
Critical Review of Prolotherapy for Osteoarthritis, Low Back Pain, and other Musculoskeletal Conditions: A Physiatric Perspective
Kim, Sunny R. MD; Stitik, Todd P. MD; Foye, Patrick M. MD; Greenwald, Brian D. MD; Campagnolo, Denise I. MD, MS
http://journals.lww.com/ajpmr/Abstract/2004/05000/Critical_Review_of_Prolotherapy_for.9.aspx
“Is Platelet-Rich Plasma an Effective Healing Therapy?”
By Carina Storrs | December 18, 2009
http://www.scientificamerican.com/a...-dennis-cardone-sports-medicine-injury&page=2