IMO, blackflies and deer flies are the main villians. Most nights, the Adirondacks seem to be a bit cool for mosquitoes to be a problem. With any of the bugs, starting early in the morning is the most effective deterent. I typically try to hike repellent-free, and easily do so at least 50% of the time, even during peak blackfly season. Make sure you don't spray any other repellent near food. My wife accidentally sprayed DEET on my sandwich one day, and it's something I'd never like to ever experience again.
DEER FLIES:
I have found nothing to be effective against deer flies, other than a well-placed swat and roll. I've found if you just swat them, their bodies flatten, and they'll be circling your head again seconds later. I've tried wearing feathers, ferns, hemlock branches, etc. on my head, and it does seem to deter them from biting. However, I don't know what's worse... the biting or the circling hum.
BLACKFLIES:
If the blackflies become a nuisance (about 30% of the time), I'll either keep moving (I've found anything above 1 mph ususally deters biting) or, if standing around, apply some Bye Bye Blackfly.
If the blackflies are swarming, I'll first apply 100% DEET to my cotton baseball hat, shirt sleeves, top of socks, and pants waistline. If they are undetered, I'll applly 100% DEET to elbows, ears, back of neck, and temples. Only on a couple of occassions have I needed to cover all exposed skin. I've used 100% DEET for years, and have not had any issues with it dissolving any plastics other than the sandwhich bag I keep it in that I replace each year. Even at the end of the year, the bag is still waterproof, it just looks opaque.
One day, many years back, they were so bad that I put on my raincoat w/ hood even though it was about 85*F. They were bouncing off so frequently that it sounded like rain. We knew we were in trouble when we brought out the DEET, and they attacked the bottle. Whenever my hiking partner touched a tree, I could see them leaving their perches en masse. When we got back to the trailhead, I noticed my socks were soaked with blood. I had scars around my sock-line for the next 6-8 months.
BTW... the next time you are being attacked... try to remember that bugs are supreme touron deflectors, and thus, are the under-appreciated saviors of the backcountry.