Experience ...
I really never paid much attention to data file size when we routinely scanned our negatives for pre-press processing. I do know, however, that they were significantly large files. We usually produced them initially as TIFFs to be worked up for use in the newspaper, but archived them as compressed JPGs.
Right now, it escapes me as to the quality level (dpi) at which we scanned our negs. I am sure it was not the highest, nor was it the lowest. I do know, however, that a scanned 35mm negative easily could be enlarged to the 16” X 20” or even 20” X 24” or beyond without serious image deterioration (especially for our purposes). We could easily reproduce images the size of a broadsheet newspaper page. Our big quality limitation was repro on newsprint.
Scanning speed slows way down as you push the quality up. Producing higher quality scans entails evaluating and perhaps tweaking the image density (brightness), contrast and color characteristics before the actual scan is made. It is not a process that lends itself to high level automation with something like the Nikon Coolscan units. Plus, the scans themselves take longer to run as you increase the quality specs.
As mentioned earlier, we used one of the Nikon Coolscan models, ca 2000-01. Before that, we had used a Polaroid scanner -- not nearly as good. When we changed over from using Ektacolor to Portra neg films – the scanned colors produced by that unit were hideous. That was a scanner software problem. Later, we used Fujicolor films and switched to the Nikon scanner, and produced generally decent color renditions at all ISOs, and even with push-processed high speed films.
Using the Nikon Coolscan, we did eventually have problems with the sharpness of our scanned images – manifested as loss of focus on one or both edges of the frame. This was due to breakage of plastic “springs” that were supposed to pinch and hold the negative carrier solidly in place. Loss of compression on the carrier allowed the negatives to buckle.
The Nikon Coolscan had digital ICE technology. We used it, and found it quite effective. But it is not perfect. Some additional touching-up of dust spots had to be done in Photoshop.
Understand that we were handling selected images. We did not digitize entire shoots. Scanned images were archived on a server hard drive, and periodically batched to be burned on CDs.
G.